Life is controlled by a milieu of macromolecular interactions. We focus on understanding structural basis for protein interactions and their applications using a variety of biophysical and biochemical techniques such as crystallography and solution scattering as well as standard techniques in molecular cell biology. We study proteins interactions in ubiquitin signaling, host-pathogen relationship and abiotic stress response signaling. We also develop mini-antibody based bionano sensors for both diagnostic and therapeutic purposes.
Education
(PhD) 2003 University of California, Los Angeles
Experience
2013 Jul ~ 2014 Aug Visiting Scholar, University of California, Los Angeles
2007 Mar ~ Present Assistant and Associate Professor, Department of Biological Sciences, Sungkyunkwan University
2004 Sep ~ 2007 Feb Visiting Fellow, National Institutes of Health
2003 Dec ~ 2004 Aug Postgraduate Researcher, University of California, Los Angeles
2013 Dec ~ Present Editorial Board, Biodesign Journal
Journal Articles
(2025)
Structural basis for malate-driven, pore lipid-regulated activation of the Arabidopsis vacuolar anion channel ALMT9.
NATURE COMMUNICATIONS.
16,
1
(2024)
Dopamine-conjugated extracellular vesicles induce autophagy in Parkinson's disease.
JOURNAL OF EXTRACELLULAR VESICLES.
13,
12
(2024)
Crystal structure of an antibody specifically recognizing 3,4-methyl enedioxy methamphetamine through the epoxide moiety.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.
733,
(2024)
Tacrolimus-loaded chitosan-based nanoparticles as an efficient topical therapeutic for the effective treatment of atopic dermatitis symptoms.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.
273,
(2024)
Selective Binding of Tannic Acid-Conjugated Lipid Nanovesicles to Proline-Rich Proteins Enhances Transdermal Lipophilic-Antioxidant Delivery.
ACS Applied Bio Materials.
7,
6
(2024)
Design and optimization of a continuous purification process using ion‑exchange periodic counter‑current chromatography for a low‑titer enzyme.
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING.
29,
1
(2023)
Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model.
NATURE COMMUNICATIONS.
14,
1
(2023)
Discovery of highly immunogenic spleen-resident FCGR3(+)CD103(+) cDC1s differentiated by IL-33-primed ST2(+) basophils.
CELLULAR & MOLECULAR IMMUNOLOGY.
20,
7
(2023)
Blockade of Activin Receptor IIB Protects Arthritis Pathogenesis by Non-Amplification of Activin A-ACVR2B-NOX4 Axis Pathway.
ADVANCED SCIENCE.
10,
14
(2020)
ClpL is a functionally active tetradecameric AAA plus chaperone, distinct from hexameric/dodecameric ones.
FASEB JOURNAL.
34,
11
(2020)
Blocking of the IL-33/ST2 Signaling Axis by a Single-Chain Antibody Variable Fragment (scFv) Specific to IL-33 with a Defined Epitope.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
21,
18
(2020)
Ectopic Expression of OsPYL/RCAR7, an ABA Receptor Having Low Signaling Activity, Improves Drought Tolerance without Growth Defects in Rice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
21,
11
(2020)
Atomic structures determined from digitally defined nanocrystalline regions.
IUCRJ.
7,
1
(2020)
Selection and functional identification of a synthetic partial ABA agonist, S7.
SCIENTIFIC REPORTS.
10,
1
(2020)
Selection and functional identification of a synthetic partial ABA agonist, S7..
SCIENTIFIC REPORTS.
10,
1
(2019)
Comprehensive survey of the VxG phi L motif of PP2Cs from Oryza sativa reveals the critical role of the fourth position in regulation of ABA responsiveness.
PLANT MOLECULAR BIOLOGY.
101,
4-5
(2019)
Crystal Structure of IlvC, a Ketol-Acid Reductoisomerase, from Streptococcus Pneumoniae.
CRYSTALS.
9,
11
(2019)
Structural determinants for pyrabactin recognition in ABA receptors in Oryza sativa.
PLANT MOLECULAR BIOLOGY.
100,
3
(2019)
Two Clade A Phosphatase 2Cs Expressed in Guard Cells Physically Interact With Abscisic Acid Signaling Components to Induce Stomatal Closure in Rice.
RICE.
12,
1
(2019)
Antibody reformatting vector system (AbVec): a platform for converting single-chain variable fragment format to other ones using shared restriction enzyme sites.
Biodesign.
7,
1
Publications
(2022)
Methods in Molecular Biology Volume 2462. Abscisic Acid
Chapter 1. Inhibition of Type 2C Protein Phosphatases by ABA Receptors in Abscisic Acid–Mediated Plant Stress Responses.
Humana.
Lead author
(2012)
Annual Plant Reviews, Volume 44, The Plant Hormone Ethylene
Chapter 7 EIN2 and EIN3 in Ethylene signaling.
Wiley.
Co-author
Patent/Intellectual Property
폐렴연쇄상구균의 Pep27에 특이적인 단일클론 항체.
19-0291-7091945.
20200519.
KOREA, REPUBLIC OF
Conference Paper
(2024)
BioSAXS-derived mechanisms for differential regulation of Rab GTPases by site-specific monoubiquitination.
XIX International Small Angle Scattering Conference.
TAIWAN
(2024)
Structural Basis of Selective Recognition of MDMA over METH by Antibody Targeting Epoxide Moiety.
2024년 한국결정학회 정기학술대회.
KOREA, REPUBLIC OF
(2024)
Structure-based activation mechanism of the plant anion channel SLAC1.
2024년 한국결정학회 정기학술대회.
KOREA, REPUBLIC OF
(2024)
Application of bioSAXS to explore conformational space of protein complexes for differential functionalities.
2024 5th Korea - Nordic Strateic Seminar for Research Collaboration.
SWEDEN
(2024)
Molecular insights into the activation of plant anion channel SLAC1 for stomatal closure.
2024 한국생물물리학회 연례학술대회.
KOREA, REPUBLIC OF
(2024)
Crystal Structure of an Antibody Recognizing 3,4-methylenedioxymethamphetamine Reveals Selectivity over Methamphetamine through an Epoxide Moiety.
2024 ISSD & KSSB Joint Symposium.
KOREA, REPUBLIC OF
(2024)
Screening and Cryo-EM Structure of an Antibody Specific to the Receptor Binding Domain of the SARS-CoV-2 Spike Protein.
2024 ISSD & KSSB Joint Symposium.
KOREA, REPUBLIC OF
(2024)
Cryo-EM structures of the plant anion channel SLAC1 reveal the activation mechanism by combining binding-activation and inhibition-release models.
단백질 구조 결정을 통한 생물학적 기능 해석.
KOREA, REPUBLIC OF
(2024)
Structural basis for activation of the plant anion channel SLAC1 from Arabidopsis thaliana in abscisic acid signaling.
2024년 한국구조생물학회 동계연례학술대회.
KOREA, REPUBLIC OF
(2023)
Analysis of the interaction of DOG1 with AHG1 using size exclusion chromatography coupled small-angle X-ray scattering.
한국결정학회 정기학술대회.
KOREA, REPUBLIC OF
(2023)
A Combined Activation Mechanism of ‘Master Switch’ SLAC1.
한국구조생물학회 하계연학술대회.
KOREA, REPUBLIC OF
(2020)
Structural and biochemical studies of ClpL, an active tetradecameric AAA+ family chaperone.
제126회 대한화학회 학술발표회.
KOREA, REPUBLIC OF
(2020)
Determining Atomic Structures from Digitally Defined Regions of Nanocrystals.
American Crystallographic Association Annual Meeting.
UNITED STATES
(2020)
Crystal Structure of IlvC, a Ketol-Acid Reductoisomerase from Streptococcus pneumoniae.
2020 한국생체분자과학연합학회 학술대회.
KOREA, REPUBLIC OF
(2020)
Effects of a hydrophobic residue in pyrabactin recognition by a rice ABA receptor.
2020 한국생체분자과학연합학회 학술대회.
KOREA, REPUBLIC OF
(2020)
Molecular details of the VxGΦL motif of PP2Cs from Oryza sativa involved in regulation of ABA responsiveness.
2020 한국생체분자과학연합학회 학술대회.
KOREA, REPUBLIC OF
(2019)
Crystallographic and computational analyses reveal that the fourth position of VxGΦL motif in type 2C protein phosphatases is critical in regulating abscisic acid signaling.
16th Conference of the Asian Crystallographic Association.
SINGAPORE
(2019)
A tryptophan residue is critical in differential pyrabactin recognition by rice ABA receptors.
제31차 방사광이용자연구발표회.
KOREA, REPUBLIC OF
(2019)
Structural and biochemical analysis of IlvC from Streptococcus pneumoniae.
2019년 한국결정학회 학술대회.
KOREA, REPUBLIC OF
(2019)
THE CRITICAL ROLE OF THE FOURTH POSITION OF THE VXGFL MOTIF OF PP2CS FROM ORYZA SATIVA IN REGULATION OF ABA RESPONSIVENESS.
32nd European Crystallographic Meeting.
AUSTRIA
