1. Research objective 1: Employment of various biomaterials and biofabrication systems for regenerative medicine purposes. We aim to fabricate functional hydrogel-based biomimetic tissue substitutes for tissue regenerative applications via the investigation of various biomaterials and biofabrication systems to provide favorable cellular microenvironments for the host cells. Through in vivo assessment in an appropriate animal defect model, the regenerative efficacy of the fabricated tissue substitute will be evaluated.
2. Research objective 2: Development and design of integrative biomanufacturing system for recapitulating stem cell niche in terms of physical/chemical/biological aspects and disease microenvironments including degenerative diseases and muscular dystrophy & various cancers. We aim to design and fabricate novel hydrogel-based 3D tissue constructs with biomimetic and hierarchical architecture for stem cell fate determination, novel co-culture system, and tumor microenvironment (TME) via 3D bioprinting, cell-electrospinning, nano/microfabrication systems and develop functional in vitro disease model platforms as an organ-on-a-chip model and stem cell organoid engineering to modulate cell-cell and cell-matrix interactions for various cellular functions and their subsequent contribution to in vitro tissue model.
Education
Ph.D. in Mechanical Engineering, Univ. of Wisconsin-Madison, USA (2003)
Experience
Korea Institute of Machinery and Materials (KIMM), Senior Researcher
Samsung Electronics, R&D Center, Senior Researcher
(2025)
Bioprinting of cardiac patches with gold-nanowires and tri-culture system for the treatment of myocardial infarction.
CHEMICAL ENGINEERING JOURNAL.
526,
171562
(2025)
Catalyst-Free Collagen Filament Crosslinking for Engineering Anisotropic and Mechanically Robust Tissue Scaffolds.
ADVANCED SCIENCE.
e14319,
(2025)
Bioprinted Collagen Cell Constructs with Gradient BMP-2-Loaded Microbeads for Rotator Cuff Tear Regeneration.
ADVANCED HEALTHCARE MATERIALS.
e04150,
(2025)
Mechanosensitive Cell-Laden Shape-Memory Scaffolds Engineered via Cryogelation.
SMALL STRUCTURES.
e202500466,
(2025)
Cell-Laden Constructs with Anisotropic Pores Fabricated by Collagen/Silk-Fibroin for Muscle Tissue Regeneration.
ADVANCED FUNCTIONAL MATERIALS.
e03933,
(2025)
Comb-assisted 3D bioprinting for highly aligned 3D muscle bioconstructs with enhanced cellular mechanotransduction.
VIRTUAL AND PHYSICAL PROTOTYPING.
20,
1
(2025)
Fish-derived biomaterials for tissue engineering: advances in scaffold fabrication and applications in regenerative medicine and cancer therapy.
THERANOSTICS.
15,
12
(2025)
Bioengineered skin-substitutes incorporating rete-ridges using a bioprinting process.
INTERNATIONAL JOURNAL OF EXTREME MANUFACTURING.
7,
015501
(2025)
In situ magnetic-field-assisted bioprinting process using magnetorheological bioink to obtain engineered muscle constructs.
BIOACTIVE MATERIALS.
45,
(2025)
3D bioprinted multi-layered cell constructs with gradient core-shell interface for tendon-to-bone tissue regeneration.
BIOACTIVE MATERIALS.
43,
(2025)
Fabrication of 3D-printed coiled PCL microfibrous bundles using alginate-based biocomposites for bone tissue engineering applications.
INTERNATIONAL JOURNAL OF EXTREME MANUFACTURING.
025501,
(2024)
Stimulus-assisted in situ bioprinting: advancing direct bench-to-bedside delivery.
TRENDS IN BIOTECHNOLOGY.
2593,
(2024)
Enhanced Myogenic Differentiation of Human Adipose-Derived Stem Cells via Integration of 3D Bioprinting and In Situ Shear-Based Blade Coating.
ADVANCED FUNCTIONAL MATERIALS.
35,
1
(2024)
Bioengineered cell-constructs using decellularized fish skin-based composite bioink for regenerating muscle tissue.
APPLIED PHYSICS REVIEWS.
11,
2
(2024)
An Approach for Fabricating Hierarchically Porous Cell-Laden Constructs Utilizing a Highly Porous Collagen-Bioink.
ADVANCED FUNCTIONAL MATERIALS.
34,
26
(2024)
Engineered 3D liver-tissue model with minispheroids formed by a bioprinting process supported with in situ electrical stimulation.
BIOACTIVE MATERIALS.
35,
(2024)
Fabrication of fully aligned self-assembled cell-laden collagen filaments for tissue engineering via a hybrid bioprinting process.
BIOACTIVE MATERIALS.
36,
